According to Dawn, the attacker, who was on a motorbike, rammed into the police vehicle carrying the Additional Inspector General (AIG) Headquarters, Ashraf Noor, and other officials.
The blast, which left the police vehicle in flames appeared to be a suicide attack, Capital City Police Officer (CCPO) Tahir Khan said.
The blast occurred near the Zarghooni Mosque, when the police officials were on their way to work this morning, the CCPO added.
Khan, confirming the death of the AIG, said at least six policemen were injured and shifted to the Hayatabad Medical Complex.
The police has cordoned off the blast site and further investigation is underway.