All of the crew died in the accident after they failed to eject themselves from the aircraft.
"The Su-24 plane rolled off the runway and broke up while accelerating for takeoff... The plane's crew did not have time to eject and died," the local media reported quoting a military spokesman as saying.
Technical failure could be the reason of the accident, the Ministry added.
Over the past week, Russian jets have intensified their campaign, conducting up to 150 airstrikes per day, the reports said.
The toll of Russian servicemen officially reported killed in Syria is at 37 with these two deaths, the reports added. (ANI)