According to the Khaama Press, the 201st Silab Corps in the East, confirming the attack, said the hideout of the terror group was wiped-out and at least 13 militants were killed.
No local or security personnel were harmed in the airstrike, the officials added.
The provincial government media office, in a statement, also confirmed that 13 militants were killed in the airstrike conducted in the Gagari area.
Earlier this week, at least eight persons were killed in an explosion that struck Jalalabad in the province.
Nangarhar is among the relatively calm provinces, however, the Taliban and IS militants have increased their insurgency activities in few its remote parts during the recent years.
Both - the Taliban and Islamic State - have, of late, been targetted by sustained US airstrikes. (ANI)