The deceased include a 40-year-old woman, an 11-year-old boy, a 7-year-old boy and a 3-year-old girl, and all of them were members of the same family, local media reports said.
Five members of the same family, who managed to escape the flames, were treated at the scene before three of them were sent to Staten Island University Hospital and two were taken to Maimonides Hospital.
Five firefighters were also injured while battling the flames.
The authorities are investigating the cause of the fire as it is still not known. (ANI)