According to the local media reports, at least seven are American among several injured.
However, authorities have not disclosed the nationalities of those dead.
"We express our condolences to all those affected by this tragedy," a spokesman for the U.S. Embassy said on the crash. "We are in contact with local authorities and are working with them to determine if there were U.S. citizens on board. We will continue to monitor the situation."
The injured were rushed to the hospitals in Bacalar and Chetumal.
United States Department of State spokesperson Heather Nauert said that representatives from the U.S. mission in Mexico are reaching the spot to assist the US citizens involved.
"We know that lots of families and individuals are traveling this time of year," she said. "We're working with local authorities."
Further details are awaited. (ANI)