Pacer Umran Malik, who earned his maiden cap in the first T20I against Ireland, had a forgetful outing with the ball as he conceded 14 runs in a single over and went wicketless.
Hooda smashed 47 runs off 29 balls while Hardik played a knock of 24 runs off 12 balls, and helped Team India to chase down the target of 109 runs in just 9.2 overs, with seven wickets in hand.
For hosts, Harry Tector starred with the bat as he smashed 64 runs off 33 balls while for visitors Bhuvneshwar Kumar, Yuzvendra Chahal, Hardik Pandya, and Avesh Khan scalped one wicket apiece.
India are eyeing their first T20I series win against Proteas on home soil while for the visitors it will be important to keep intact their great record against India in their backyard.