Du Plessis is among a group of players that are no longer contracted by Cricket South Africa and it remains to be seen whether any free agents will be selected to play for the Proteas at the T20 showcase that starts in Australia in October.
Stylish opener Laura Wolvaardt and experienced quick Ayabonga Khaka have been the big winners after dominant performances for the Proteas during their recent ODI series sweep over Ireland.
With the T20I series tied at 2-2 the fifth and final match between India and South Africa here at M Chinnaswamy Stadium, Bengaluru becomes a virtual final.
India are eyeing their first T20I series win against Proteas on home soil while for the visitors it will be important to keep intact their great record against India in their backyard.
India have scored 169/6 in 20 overs with Dinesh Karthik playing a blistering knock of 55 off 27 balls. South Africa need to chase 170-run target to take an unassailable 3-1 lead in T20I series.
Despite a defeat in the last T20I, Temba Bavuma's side will take chances and will try to once again get back in winning form. While India will look forward to continuing their winning run against Proteas to level the series.