Imbalance in pH levels may cause Alzheimer's disease

Updated:6 months, 3 weeks ago IST

New Delhi, Aug 03 (ANI): Imbalance in pH value may be a cause of Alzheimer's disease, a study has found. A study conducted by Johns Hopkins Medicine scientists have found new evidence in lab-grown mouse brain cells, called astrocytes, that one root of Alzheimer's disease may be a simple imbalance in acid-alkaline-or pH-chemistry inside endosomes, the nutrient and chemical cargo shuttles in cells. Astrocytes work to clear so-called amyloid beta proteins from the spaces between neurons, but decades of evidence has shown that if the clearing process goes awry, amyloid proteins pile up around neurons, leading to the characteristic amyloid plaques and nerve cell degeneration that are the hallmarks of memory-destroying Alzheimer's disease. To measure the pH balance within endosomes without breaking open the astrocyte, researchers used pH-sensitive probes that are absorbed by endosomes and emit light based on pH levels. The experiment successfully reversed the pH problem and improved the capacity for amyloid beta clearance. The study appeared in the Proceedings of the National Academy of Sciences journal. The disease that affects 50 million people worldwide has no cure or no drugs, till date.

Top Videos

Updated:2 months, 2 weeks ago IST

India vs Australia: Virat Kohli, Tim Paine pose with Border–Gavaskar trophy

Updated:2 months, 3 weeks ago IST

Trump blames Schwarzenegger for The Apprentice's failure to win Emmy

Updated:4 months, 2 weeks ago IST

Deepika Padukone to play acid attack survivor for Meghna Gulzar’s next

Updated:1 year, 2 months ago IST

Watch: Rahul Gandhi takes charge as Congress President

Updated:1 year, 4 months ago IST

Operation All-Out is a success, will continue it to bring peace: Lt Gen J.S. Sandhu

Updated:1 year, 5 months ago IST

Cooperatives can change demographics of our state: CM Raman Singh

Imbalance in pH levels may cause Alzheimer's disease

Top Videos

Related Video

Researchers develop new approach to treating osteoarthritis

More interacting key to keeping older adults active

Gender transition hormone therapy may increase cardiovascular risk: Study

Future repercussions of alcohol intoxication among adolescents

Scientists find genetic vulnerability to menthol cigarette use

Now, reversible antiplatelet therapy to fight clotting, cancer metastasis

Physicists develop new method to identify antibiotics-resistant bacteria

Not love, genes may impact quality of marriage: Study

Study finds high rates of weight-based bullying among LGBTQ adolescents

Researchers find clues to a functional HIV cure

Healthy diet can beat symptoms of depression: Study

Here’s why the body may reject lung transplants

Researchers find new clues to cure HIV

Mindfulness meditation could ease chronic pain

Snoopy Facebook Research app invites Apple's wrath

Eating breakfast may not induce weight loss

Vitamin D intake could lower risk of diabetes: Study

Here’s why men should train harder, for less time

Researchers come up with synthetic skin which could help burn victims ‘feel’ again

An egg a day might reduce risk of heart disease: Study