Study says brain tumors may respond to immunotherapy

Updated:1 month ago IST

New Delhi, Dec 12 (ANI): A slow-growing brain tumor in patients affected by neurofibromatosis type 1 (NF1) may be vulnerable to immunotherapy, which helps to boost the immune system in fighting cancer. It shows that a lot of have NF1, a hereditary disease that can lead to the development of tumors throughout the nervous system, including a type of brain tumor called a glioma. Gliomas are most highly resistant to chemotherapy and radiotherapy aggravates, rather than relieve, symptoms, such as headaches and seizures. Since the tumors typically engulf delicate brain regions, surgery is rarely an option. Immunotherapy has been successful for some patients with melanoma, lymphoma, and a few other types of cancer. But some clinical trials have shown that it is ineffective for brain cancers in general. Researchers have performed an in-depth analysis of tumor samples from 56 patients to create the first comprehensive inventory of the genetic, epigenetic, and immune alterations in NF1 gliomas. The study revealed that many slow-growing NF1 gliomas contain few macrophages and produce proteins, called neoantigens that can trigger an immune system attack.

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